From: Value of next-generation sequencing in inherited arrhythmia syndromes
Gene sequencing method | Total (nā=ā36) | NGS (nā=ā17) | Sanger (nā=ā19) | P value |
---|---|---|---|---|
Clinical diagnosis | ||||
Brugada syndrome | 17 (47.2%) | 13 (76.5%) | 4 (21.1%) | ā<ā0.001 |
Long QT syndrome | 2 (5.6%) | 0 (0.00%) | 2 (10.5%) | 0.163 |
Catecholaminergic polymorphic VT | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | ā |
Arrhythmogenic RV cardiomyopathy | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | ā |
Idiopathic ventricular fibrillation | 12 (33.3%) | 0 (0.00%) | 12 (63.2%) | ā<ā0.001 |
etc | 2 (5.6%) | 1 (5.9%) | 1 (5.2%) | 0.938 |
Non-diagnosed family | 3 (8.3%) | 3 (17.6%) | 0 (0.00%) | 0.083 |
ECG rhythm at initial recovery | ||||
Heart rate | 83.8āĀ±ā4.0 | 76.2āĀ±ā4.2 | 90.5āĀ±ā6.2 | 0.073 |
PR interval | 175.2āĀ±ā4.9 | 188.0āĀ±ā6.1 | 161.6āĀ±ā6.1 | 0.001 |
QRS width | 106.8āĀ±ā3.2 | 104.6āĀ±ā3.5 | 108.7āĀ±ā5.3 | 0.534 |
QT interval | 385.4āĀ±ā7.3 | 383.9āĀ±ā8.1 | 386.8āĀ±ā12.0 | 0.839 |
QTc interval | 443.2āĀ±ā7.6 | 424.8āĀ±ā7.0 | 459.6āĀ±ā11.9 | 0.017 |
Normal sinus rhythm | 18 (50.0%) | 10 (58.8%) | 8 (42.1%) | 0.331 |
Atrial fibrillation | 7 (19.4%) | 1 (5.9%) | 6 (31.6%) | 0.048 |
AV block (2nd or 3rd degree) | 4 (11.1%) | 4 (23.5%) | 0 (0.00%) | 0.041 |
Premature ventricular complex | 7 (19.4%) | 2 (11.8%) | 5 (26.3%) | 0.276 |
Brugada pattern ECG | 15 (41.7%) | 11 (64.7%) | 4 (21.1%) | 0.007 |
ECG diagnosis at SCD | ||||
Ventricular fibrillation | 21 (58.3%) | 5 (29.4%) | 16 (84.2%) | ā<ā0.001 |
Ventricular tachycardia | 3 (8.3%) | 1 (5.9%) | 2 (10.5%) | 0.627 |
Sinus pause | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | ā |
Not documented | 12 (33.3%) | 11 (64.7%) | 1 (5.2%) | ā<ā0.001 |