|
Biomarker
|
Unadjusted HR (95% CI)
|
p value
|
Adjusted HR* (95% CI)
|
p value
|
|---|
|
Platelet count (≥ 185 × 109/L)
|
0.36 (0.10–1.26)
|
0.11
|
0.35 (0.10–1.25)
|
0.11
|
|
PDW (≥ 13.2%)†
|
3.22 (0.91–11.42)
|
0.07
|
3.35 (0.94–11.91)
|
0.06
|
|
RDW (≥ 13.5%)†
|
6.35 (1.84–21.93)
|
< 0.01
|
5.67 (1.62–20.08)
|
< 0.01
|
|
Creatinine (≥ 1.11 mg/dL)†
|
3.62 (1.05–12.49)
|
0.04
|
3.51 (1.02–12.14)
|
0.047
|
|
D-dimer (≥ 0.23 μg/mL)
|
1.68 (0.48–5.97)
|
0.42
|
1.69 (0.48–6.00)
|
0.42
|
|
Troponin I (≥ 0.01 ng/mL)
|
1.49 (0.43–5.13)
|
0.53
|
1.19 (0.33–4.22)
|
0.79
|
- Biomarkers were converted into binary variables based on the optimal cutoff using maximal log-rank statistics
- CI confidence interval; HR hazard ratio; PDW platelet distribution width; RDW red cell distribution width
- *Adjusted for anticoagulant use and CHA2DS2–VASc score
- †The biomarker with p value < 0.10 was considered as a significant biomarker in prediction of incident ischemic stroke
