Prognostic value of routine blood tests along with clinical risk factors in predicting ischemic stroke in non-valvular atrial fibrillation: a prospective cohort study

Table 2 Identification of significant biomarkers in prediction of incident ischemic stroke

Biomarker	Unadjusted HR (95% CI)	p value	Adjusted HR^* (95% CI)	p value
Platelet count (≥ 185 × 10⁹/L)	0.36 (0.10–1.26)	0.11	0.35 (0.10–1.25)	0.11
PDW (≥ 13.2%)^†	3.22 (0.91–11.42)	0.07	3.35 (0.94–11.91)	0.06
RDW (≥ 13.5%)^†	6.35 (1.84–21.93)	< 0.01	5.67 (1.62–20.08)	< 0.01
Creatinine (≥ 1.11 mg/dL)^†	3.62 (1.05–12.49)	0.04	3.51 (1.02–12.14)	0.047
D-dimer (≥ 0.23 μg/mL)	1.68 (0.48–5.97)	0.42	1.69 (0.48–6.00)	0.42
Troponin I (≥ 0.01 ng/mL)	1.49 (0.43–5.13)	0.53	1.19 (0.33–4.22)	0.79

Biomarkers were converted into binary variables based on the optimal cutoff using maximal log-rank statistics
CI confidence interval; HR hazard ratio; PDW platelet distribution width; RDW red cell distribution width
*Adjusted for anticoagulant use and CHA₂DS₂–VASc score
^†The biomarker with p value < 0.10 was considered as a significant biomarker in prediction of incident ischemic stroke

ISSN: 2466-1171