Table 4 Different cutoff points of the ACAChE score to predict poor anticoagulant control on warfarin (TTR < 65%)

Sensitivity

97.3

(95.8–98.4)

95.8

(93.9–97.2)

68.1

(64.4–71.7)

43.8

(39.9–47.8)

35

(31.3–38.9)

19.5

(16.5–22.8)

13.8

(11.2–16.7)

Specificity

2.65

(0.98–5.69)

3.54

(1.54–6.86)

47.3

(40.7–54.1)

75.2

(69.1–80.7)

83.2

(77.7–87.8)

93.4

(89.3–96.2)

95.1

(91.5–97.5)

Likelihood ratio (+)

1.00

(0.975–1.03)

0.993

(0.964–1.02)

1.29

(1.13–1.48)

1.77

(1.39–2.26)

2.08

(1.53–2.83)

2.93

(1.75–4.9)

2.84

(1.55–5.21)

Likelihood ratio (−)

1.01

(0.401–2.52)

1.2

(0.552–2.6)

0.673

(0.563–0.804)

0.747

(0.675–0.827)

0.781

(0.72–0.848)

0.863

(0.819–0.908)

0.906

(0.868–0.946)

Odd ratio

0.995

(0.399–2.48)

0.829

(0.378–1.82)

1.92

(1.41–2.62)

2.37

(1.69–3.32)

2.66

(1.82–3.91)

3.4

(1.96–5.91)

3.13

(1.66–5.92)

Positive predictive value

73.8

(70.7–76.8)

73.7

(70.5–76.6)

78.5

(74.8–81.8)

83.3

(78.8–87.1)

85.4

(80.6–89.5)

89.2

(82.8–93.8)

88.9

(81–94.3)

Negative predictive value

26.1

(10.2–48.4)

22.9

(10.4–40.1)

34.5

(29.2–40.1)

32.2

(28.2–36.4)

31.2

(27.5–35.1)

29.1

(25.9–32.6)

28.1

(25–31.5)

Accuracy

72.54

(69.43–75.49)

71.61

(68.47–74.6)

62.69

(59.36–65.93)

52.03

(48.63–55.41)

47.62

(47.71–54.49)

38.82

(35.55–42.16)

35.11

(31.92–38.4)

p value

0.991

0.647

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001