Lower dementia risk with anticoagulation and ablation in patients with atrial fibrillation

Table 1 Association between atrial fibrillation and dementia

Study (Year of publication)	Follow-up duration (years)	Age (years) of population (mean or median)	Types of dementia	Incidence of dementia		Increased dementia risk for AF (OR or HR [95% CI])
Study (Year of publication)	Follow-up duration (years)	Age (years) of population (mean or median)	Types of dementia	AF	No AF	Increased dementia risk for AF (OR or HR [95% CI])
Ott et al. [10] (1997)	Cross-sectional	67.9	All-cause	-	-	2.3 (1.4–3.7)
			AD	-	-	1.8 (1.0–3.3)
			VaD	-	-	1.9 (0.6–5.5)
Bunch et al. [7] (2010)	5.3	60.6	All-cause	3.3%	1.3%	1.44
			AD	1.5%	0.7%	1.06
			SD	1.6%	0.6%	1.39
			VaD	0.9%	0.3%	1.73
Dublin et al. [11] (2011)	6.8	74.3	All-cause	4.8%/yr	2.5%/yr	1.38 (1.10–1.73)
Dublin et al. [11] (2011)	6.8	74.3	AD	3.8%/yr	2.0%/yr	1.50 (1.16–1.94)
Marengoni et al. [12] (2011)	4.0	78	All-cause	7.2%/yr	6.4%/yr	0.9 (0.5–1.7)
Marengoni et al. [12] (2011)	4.0	78	AD	5.5%/yr	5.2%/yr	0.8 (0.4–1.5)
Kim et al. [8] (2019)	7.2	71.7	All-cause	4.1%/yr	2.7%/yr	1.52 (1.43–1.63)
			AD	2.2%/yr	1.6%/yr	1.31 (1.20–1.43)
			VaD	1.1%/yr	0.5%/yr	2.11 (1.85–2.41)

AD Alzheimer’s disease, AF atrial fibrillation, CI confidence interval, HR hazard ratio, OR odds ratio, SD senile dementia, VaD vascular dementia

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