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Table 2 References for atrial cell ion currents depending on AADs

From: Computational modeling of atrial fibrillation

AADs Referencew Animal/human model Method Ion current change
Amiodarone
(5 μM, 10 μM)
Varela et al. [50] Canine atrial model Microelectrode recording and patch-clamp gK1, gKur, gNa, gKr, gCaL, gKs
Ach
Sotalol
(60 μM, 10 mM)
Ducroq et al. [51]
Lin et al. [52]
Rabbit/Human embryonic kidney cells
Xenopus oocytes
Bipolar Ag electrode recoding and patch clamp
Two-electrode voltage clamp
gNa, gKr, gKs
Dronedarone
(3 μM, 10 μM)
Chen et al. [53]
Gautier et al. [54]
Ji et al. [55]
Wegener et al. [56]
Rat
Guinea pig ventricular cardiomyocyte
Dog ventricular myocytes
Guinea pig myocytes
Whole-cell, perforated patch voltage-clamp gCaL, gKs, gNa, gK1, gKr, gCaL
Flecainide
(5 μM, 15 μM)
Geng et al. [57]
Yue et al. [58]
Wang et al. [59]
Hilliard et al. [60]
Human pluripotent stem cell-derived ventricular cardiomyocyte
Human right atrial appendage
Human pluripotent stem cell-derived ventricular cardiomyocyte
Canine, murine ventricular model
Whole-cell patch voltage clamp, microscope, and confocal laser-scanning unit gNa, gKur, gNa, gto, gCaL
Propafenone
(5 μM, 10 μM)
Wang et al. [61]
Paul et al. [62]
Seki et al. [63]
Delgado et al. [64]
Human Embryonic kidney cells
Human atrial myocytes
Guinea pig ventricular myocytes
Whole-cell patch voltage clamp gNa, gto, gCaL, gKur, gKr,