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Table 1 Selective indications of ICD implantation for HFpEF [69]

From: Sudden cardiac death in heart failure with preserved ejection fraction: an updated review

Clinical indications

Conditions

Lamin A/C mutation

≥ 2 risk factors (NSVT, LVEF < 45%, nonmissense mutation, and male sex) (COR IIa)

HCM

 > 1 of the following risk factors (COR IIa)

Maximum LV wall thickness ≥ 30 mm

SCD in ≥ 1 first-degree relatives presumably caused by HCM

 ≥ 1 episodes of unexplained syncope within the preceding 6 months

Spontaneous NSVT or an abnormal blood pressure response with exercise in the presence of age < 30 y, LGE on cardiac MRI, LVOT obstruction, LV aneurysm or syncope > 5 y (COR IIa)

Cardiac sarcoidosis

Syncope and/or evidence of myocardial scar by cardiac MRI or PET scan (COR IIa)

An indication for permanent pacing (COR IIa)

Inducible sustained VA at an EP study (COR IIa)

  1. ICD implantable cardioverter-defibrillator, HFpEF heart failure with preserved ejection fraction, NSVT non-sustained ventricular tachycardia, COR class of recommendation, EP electrophysiology, LVEF left ventricular ejection fraction, SCD sudden cardiac death, HCM hypertrophic cardiomyopathy, LGE late gadolinium enhancement, MRI magnetic resonance imaging, LVOT left ventricular outflow tract, PET positron emission tomography, VA ventricular arrhythmia