Short tip–more function? Atrial fibrillation ablation using the novel third-generation cryoballoon in resected pulmonary vein

Abstract

Background

Cryoballoon ablation is an established procedure for atrial fibrillation (AF). Patients who had previous pulmonary surgery undergoing pulmonary vein isolation (PVI) were seldom reported.

Case presentation

We describe an AF ablation using the novel short-tip third-generation cryoballoon in a patient with resected pulmonary vein. All pulmonary veins were successfully isolated without complication. The short-tip third-generation cryoballoon shows advantageous profile in PVI for AF patients with previous pulmonary surgery.

Conclusions

This report indicates that for AF patient who had previous resected PV surgery, the short-tip CB 3 provides an ideal device option for real-time PVI.

Introduction

Cryoballoon ablation is an established procedure for atrial fibrillation (AF). Patients who had previous pulmonary surgery undergoing pulmonary vein isolation (PVI) were seldom reported. The novel third-generation cryoballoon was designed with a short tip-to-balloon distance which may enable cyroablation in patient with atypical complex pulmonary vein anatomy. We describe an AF ablation using the novel short-tip third-generation cryoballoon in a patient with resected pulmonary vein.

Case

A 66-year-old female patient was admitted because of highly symptomatic drug-refractory paroxysmal atrial fibrillation (AF). The CHA₂DS₂-VASc score was 2 and HAS-BLED score was 2. The patient underwent pulmonary surgery and the right upper-lobe lung was resected 4 years ago because of pulmonary carcinoma. The patient has been in stable condition without evidence of progression. Transesophageal echocardiography (TEE) was performed at admission, and left atrial (LA) thrombus was ruled out. After multidisciplinary assessment, we suggested pulmonary vein isolation (PVI) using cryoballoon technology. Full consent of the patient was obtained.

Detailed procedural approach was published previously [1,2,3]. In this case, after single transseptal puncture, selective PV angiography was performed to identify the pulmonary vein. The right superior PV (RSPV) was shown as a “short-stub” anatomy due to the previous pulmonary surgery (Fig. 1). Therefore, a shorter-tip third-generation cryoballoon (CB 3, Arctic Front Advance Pro., Medtronic) was selected for PVI.

Fig. 1

Sequential baseline pulmonary vein angiography. a Baseline left superior PV (LSVP) angiography. b Baseline left inferior PV (LIPV) angiography. c Baseline right inferior PV (RIPV) angiography. d Baseline right superior PV (RSPV) angiography showed a “short-stub” anatomy due to the previous pulmonary surgery

All four PVs were treated with time-to-effect guided freeze. Particularly, the short-tip CB 3 and spiral mapping catheter combination obtained a perfect occlusion for the operated RSPV. Figure 2 details the approaches, catheter maneuver, PV occlusion and electrophysiological tracing during RSPV ablation. Consequently, the RSPV was well occluded and real-time isolated using a “push-up” maneuver. In-hospital, 1, 3, 6 months’ follow-up showed favorable clinical outcome. 72-h Holter at each follow-up visit did not reveal AF/AT recurrence.

Fig. 2

Isolation of the RSPV using CB3 with the “push-up” maneuver. A shorter-tip third-generation cryoballoon (CB 3, Arctic Front Advance Pro., Medtronic) was selected for PVI. The transseptal sheath was exchanged over a guidewire for a 12-Fr steerable sheath (Flexcath Advance, Medtronic). The 28-mm CB 3 was advanced into the LA via the 12-Fr steerable sheath under the guidance of spiral mapping catheter (Achieve, 20 mm, Medtronic). A temperature probe (Sensitherm, St. Jude Medical) was advanced into the esophagus to monitor esophageal temperatures during freeze. During freeze the right PVs, phrenic nerve (PN) function was monitored by continuous PN pacing using a diagnostic catheter positioned at the superior vena cava (7-Fr, ParaHis, Biosense Webster). Pacing was set at maximum output and pulse width (12 mA, 2.9 ms) and a cycle length of 1200 ms. PN pacing-generated “Compound motor action potential” (CMAP) was continuously monitored during freeze. a First angiography showed contrast leak at the roof of RSPV. b After a push-up maneuver, the second angiography showed that the RSPV was perfectly occluded and real-time isolated within 50 s, minimal temperature was − 56 °C, freeze duration was set at 240 s, without evidence of PN palsy and PV perforation. c Electrogram showed the moment of RSPV isolation and continuous CMAP monitoring for PN function

Discussion

With respect to the former second-generation cryoballoon device, the third-generation cryoballoon has been designed with a 40% shortened tip length [4]. Theoretically, a shorter tip should permit an improved visualization of the electrical activity in the PV due to a more proximal positioning of the circular mapping catheter. Moreover, a shorter-tip design should enable appropriate application of the cryoballoon in any “short-stub” anatomic structure, i.e., atrial appendage or resected PV. In this case, we reported PVI using this novel short-tip design balloon catheter in an AF patient after pulmonary surgery.

Conclusion

This report indicates that for AF patient who had previous resected PV surgery, the short-tip CB 3 provides an ideal device option for real-time PVI.