Catheter ablation of outflow tract ventricular arrhythmia with intracardiac echocardiography assistance
International Journal of Arrhythmia volume 23, Article number: 3 (2022)
As the indications for catheter-based electrophysiologic procedures become more diverse and complex, accurate assessment of the anatomy of intracardiac structure has become essential for the optimal clinical outcome. Since intracardiac echocardiography (ICE) was first introduced in 1980, it has become an integral part of various electrophysiologic procedures enabling accurate visualization of cardiac structures and continuous monitoring of catheter position, with integration of real-time images and electroanatomic mapping. Catheter ablation for outflow tract ventricular arrhythmias (OTVAs) has been actively performed in symptomatic patients. However, the anatomic complexity of OT serves as the biggest obstacle to obtain the optimal results. In OTVAs, ICE has played an invaluable role in precisely defining the anatomic shell of OT beyond fluoroscopy and in guiding catheter manipulation in relation to critical structures like the conduction system and coronary arteries. This review article provides detailed information on comprehensive application of ICE for catheter ablation of OTVAs.
The ventricular outflow tract (OT) is the most common site of origin (SOO) for idiopathic ventricular arrhythmias (VAs) in patients without structural heart disease [1,2,3]. Multiple studies have been shown that radiofrequency catheter ablation (RFCA) can be successfully performed in OT with high success and low complication rates [4, 5]. The current guidelines recommend RFCA as a preferred therapy in patients with symptomatic OTVAs . However, structural complexity, anatomic variation, and proximity to the conduction system and coronary vasculature serve as the biggest obstacles to successful ablation. Therefore, accurate knowledge of the regional anatomy of these overlapping structures is essential for the effective and safe ablation of OTVAs. Although three-dimensional (3D) mapping with fluoroscopy is often sufficient for guiding catheters, more detailed anatomic information is needed in many cases, especially in the left ventricular outflow tract (LVOT).
Since intracardiac echocardiography (ICE) was introduced in the 1980s, technological advances have continued, making it an integral part of various cardiac interventions . In the field of electrophysiology, ICE allows accurate visualization of cardiac structures and continuous monitoring of catheter position, with integration of real-time images and electroanatomic mapping (EAM) [8, 9]. In OTVAs, ICE has played an invaluable role in precisely defining the anatomic shell of OTs beyond fluoroscopy and in guiding catheter manipulation in relation to critical structures like the conduction system and coronary arteries. These roles could contribute to improving clinical outcomes and reducing complications [10, 11]. From this point of view, we provide detailed information on comprehensive application of ICE for catheter ablation of OTVAs through this review article.
Introduction of the ICE system
The current ICE catheter used in electrophysiologic procedures consists of a 64-element, phased array transducer capable of high-resolution 2D and full Doppler/color flow imaging . The ICE probe provides a 90-degree sector image perpendicular to the long axis of the catheter with tissue penetration of 15 to 18 cm. The currently available ICE catheters in South Korea are the SOUNDSTAR®/ACUSON AcuNav™ (Biosense Webster, Inc., Diamond Bar, CA) and ViewFlex™ Xtra (Abbott, Inc., Chicago, IL). Both ICE catheters can steer the catheter tip bidirectionally in two planes (antero-posterior and right–left) by manipulating the control handle . The ICE image is conventionally displayed in the orientation where the right side of the screen is superior anatomically and the downside of the screen indicates a far field from the transducer. The comparison of ICE catheters is summarized in Table 1.
ICE views of the OT
There was no standard view for ICE, as there are for transthoracic echocardiography and transesophageal echocardiography. However, some viewpoints can be useful in assessing the anatomy of the OTs. An ICE catheter can be easily advanced through the femoral vein into the right atrium (RA) without fluoroscopic guidance by an experienced operator. The ICE study is usually initiated with the “home view” acquired from the ICE catheter positioned in the mid-RA facing tricuspid valve (TV) (Fig. 1a). This view allows superb visualization of the TV and right ventricular (RV) inflow tract. A comprehensive evaluation of the OTs can be conducted in the RA and RV.
From the RA
The catheter is rotated clockwise with a neutral position from the home view to visualize the right ventricular outflow tract (RVOT) in the RA (Fig. 1a). In this view, the RVOT is seen just below the aortic root. The anterior (or septal) TV leaflet is visualized at 3 o’clock and is closed to the aortic root opposing the posterior leaflet at 9 o’clock.
From the RVOT view, the slightly clockwise rotation of the catheter will reveal the LVOT and aortic root in the long axis (Fig. 1b). On the other hand, the pulmonic valve (PV) will be shown in the short axis just behind the aortic valve (AV) since the OTs intersect at their origins on the disparate axis. In this view, the non-coronary cusp (NCC) is adjacent to the RA and TV in a close relationship with the parahisian region, whereas the opposite cusp is the right coronary cusp (RCC) close to the RVOT infundibulum. Further clockwise rotation facing the posterior and leftward side of the heart visualizes the LV cavity, anterior mitral leaflet (AML), and left atrium.
A short-axis view of the LVOT in the RA can be obtained by combining leftward control handle movement and clockwise rotation of the catheter. This view provides an excellent transverse image of the AV with a typical trileaflet appearance (Fig. 1c).
From the RV
From the home view, the curved catheter can be advanced across the TV with combined anterior and leftward movements of the control handle. Once the catheter tip passes through the TV, a slight release of the anterior curve will enable the catheter to advance further into the RV. In this catheter location, the RVOT and PV are viewed clearly in the long axis with the more distal part of the main pulmonary artery (Fig. 2a). The pulmonary cusp closest to the AV is the left pulmonary cusp (LPC), while the anterior pulmonary cusp (APC) is observed on the opposite side. Further advancement of the catheter allows visualization of the main pulmonary artery bifurcation.
A transverse view of the LVOT can be obtained inside the RV cavity as well as in the RA. First, the anteriorly curved catheter is advanced gently into the RV, and then the anterior deflection is released. By rotating the catheter clockwise, the transducer beam will move from the inferior RV to the LV cavity. The interventricular septum (Fig. 2b), posteromedial papillary muscle (Fig. 2c), anterolateral papillary muscle, and LV basal structures such as the AML and aorto-mitral continuity (AMC) are observed sequentially as the catheter rotates (Fig. 2d and e). With further clockwise rotation of the catheter from the view of the LV base, a transverse section of the aortic root comes into view with a typical Mercedes-Benz symbol (Fig. 2f). The cusp visualized nearest to the transducer is the RCC. The left coronary cusp (LCC) and NCC are observed in a clockwise manner from the RCC. From this view, the ostia of the left (Fig. 2g) and right coronary arteries (Fig. 2i) can be identified. In addition, careful counterclockwise rotation of the catheter allows for tracking of the left anterior descending artery (LAD) (Fig. 2H). On the other side, tracking of the right coronary artery (RCA) can be achieved from the RVOT looking up toward the aorta on the long axis. The RCA is observed just below the RCC.
Guidance of OTVA ablation using ICE
The shape, length, and size of the pulmonary infundibulum vary from patient to patient and are independent of RV size [13, 14]. Therefore, the precise anatomic boundaries of the RVOT cannot be obtained by fluoroscopy alone, resulting in incomplete mapping of the SOO or damage to the thin RV free wall. This can be prevented by delineating the anatomic shell of the RVOT with the ICE before EAM (Fig. 3). The long- and short-axis views of the RVOT provide accurate boundaries of the supra- and infra-valvular regions and pulmonary semilunar leaflet. The LAD lies near the LPC and APC. It was reported that catheter ablation in the RVOT was associated with occlusion of LAD . Additionally, severe pulmonary valve insufficiency with moderate proximal pulmonary artery stenosis was reported following RFCA ablation guided by EAM . Complication during RVOT ablation is rare [4, 5] and is hindered by ICE assessment of the precise regional anatomy with continuous monitoring of the catheter position in critical structures such as valves and coronary arteries.
The rare but most serious complication during LVOT ablation is coronary artery injury. A recent systematic review article including 43 studies has reported three cases of coronary injury during LVOT and SoV ablation . Although coronary angiography is usually performed before ablation, it is difficult to accurately determine the relationship between the actual positions of the catheter and the coronary artery during the entire cardiac cycle using fluoroscopy. Furthermore, aortic valve injuries during catheter ablation for VAs are rare but possible . The short-axis view in the RV provides an accurate location of the ostium and course of the coronary arteries, as well as an excellent transverse view of the AV. Ablation at least 1 cm from the coronary ostium is generally safe . Therefore, ICE use can overcome the limitations of fluoroscopy-based ablations, allowing for real-time visualization of the ablation catheter considering its proximity to the coronary artery.
ICE use also enables continuous monitoring of catheter-tissue contact, enabling effective energy delivery to the arrhythmogenic substrate. In addition, lesion formation can be identified as increased echogenicity and tissue thickness during ablation (Fig. 4) . For these reasons, the utilization of ICE will enhance the effectiveness of catheter ablation.
The CARTO® 3D mapping system with the CARTOSOUND® module (Biosense Webster) can superimpose EAM on ICE-generated 3D images. There are several advantages that can be obtained by integrating ICE 3D images with EAM. First, precise delineation of the anatomic contour of the OTs using ICE enables more meticulous EAM that is essential to find SOO. Without clear anatomical boundaries, locations that are hard to reach with a mapping catheter can be omitted. However, acquisition of the anatomic shell of OT using ICE before EAM can guide EAM without missing spots. Second, the integration of 3D ICE images with EAM is particularly beneficial in mapping aortic SoV and coronary arteries that are not well visualized by fluoroscopy and EAM. When LVOT VA is suspected, the location of the aortic cusps and ostium and proximal course of the coronary arteries is initially delineated using ICE. Then, this anatomic information can be added to the 3D EAM to ensure a safe distance from coronary arteries without the need for a coronary angiogram or preprocedural imaging such as cardiac computed tomography and magnetic resonance imaging. Therefore, it will enhance the ability to map and determine the SOO of arrhythmias and reduce radiation exposure.
Understanding the complex anatomic relationship of OTs and accurate localization of critical structures like coronary arteries is essential to obtain the optimal results. ICE utilization with or without integration with electroanatomic mapping provides high-quality real-time visualization of cardiac structures and continuous monitoring of catheter location with ablation lesion formation, resulting in improved clinical outcomes of OTVA ablation. Randomized studies to investigate the efficacy and safety of ICE use in OTVA ablation are warranted.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Anterior mitral leaflet
Anterior pulmonary cusp
Left anterior descending
Left anterior oblique
Left coronary cusp
Left pulmonary artery
Left pulmonary cusp
Left ventricular outflow tract
Main pulmonary artery
Posterior mitral leaflet
Right anterior oblique
Right coronary artery
Right coronary cusp
Radiofrequency catheter ablation
Right pulmonary artery
Right ventricular outflow tract
Site of origin
Sinus of valsalva
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Choi, JH., Park, KM. Catheter ablation of outflow tract ventricular arrhythmia with intracardiac echocardiography assistance. Int J Arrhythm 23, 3 (2022). https://doi.org/10.1186/s42444-021-00054-8
- Outflow tract
- Intracardiac echocardiography
- Catheter ablation
- Ventricular arrhythmia